Effect of Elastomull® elastic bandaging on second-degree burn wound healing in Wistar rats: A preliminary study
Abstract
Background: Second-degree burns are the most common burn injuries, requiring effective wound management to prevent complications. While silver sulfadiazine is the gold standard treatment, the role of elastic bandaging in enhancing healing remains unclear.
Objective: To investigate the effectiveness of Elastomull® elastic bandaging combined with silver sulfadiazine in treating second-degree burns in Wistar rats.
Methods: Six male Wistar rats were divided into two groups: K(+) group treated with silver sulfadiazine and Elastomull® bandaging, and K(-) group treated with silver sulfadiazine alone. Second-degree burns were induced using a 100°C iron applied for 5 seconds. Wound areas were measured every three days for 18 days and analyzed using Independent-Samples T-Test.
Results: The K(+) group consistently showed smaller wound areas from day 3 onwards, with greater total healing (1.87 ± 0.25 cm²) compared to K(-) group (1.03 ± 0.53 cm²). However, differences were not statistically significant (p > 0.05).
Conclusion: Elastomull® bandaging showed clinical trends toward improved burn healing but lacked statistical significance, likely due to small sample size. Larger studies are needed to confirm these findings.
References
Burgess M, Valdera F, Varon D, Kankuri E, Nuutila K. The Immune and Regenerative Response to Burn Injury. Cells. 2022;11: 3073. https://doi.org/10.3390/cells11193073
Markiewicz-Gospodarek A, Kozioł M, Tobiasz M, Baj J, Radzikowska-Büchner E, Przekora A. Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice. Int J Environ Res Public Health. 2022;19: 1338. https://doi.org/10.3390/ijerph19031338
Johnson C. Management of burns. Surgery (United Kingdom). Elsevier Ltd; 2018. pp. 435-440. https://doi.org/10.1016/j.mpsur.2018.05.004
Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020;6: 11. https://doi.org/10.1038/s41572-020-0145-5
Hendy H, Lister INE. Tingkat Efektivitas Penyembuhan Luka Bakar Derajat IIA dengan Pemberian Madu dan Pemberian Salep Nebacetin pada Tikus Putih (Rattus Norvegicus). Jurnal Kedokteran dan Kesehatan. 2019;15: 130. https://doi.org/10.24853/jkk.15.2.130-134
Yakupu A, Zhang J, Dong W, Song F, Dong J, Lu S. The epidemiological characteristic and trends of burns globally. BMC Public Health. 2022;22: 1596. https://doi.org/10.1186/s12889-022-13887-2
Mulia VD, Jailani M, Rizal S, Jannah GR. Efektivitas gel madu lokal Aceh terhadap penyembuhan luka bakar pada tikus putih (Rattus norvegicus). Jurnal Bioleuser. 2019;3: 28-31. doi:https://doi.org/10.24815/j. bioleuser.v3i2.18819
Haryono W, Wibianto A, Noer Hidayat TS. Epidemiologi dan Karakteristik Pasien Luka Bakar di RSUD Cibabat dalam Periode 5 Tahun (2015 - 2020): Studi Retrospektif. Cermin Dunia Kedokteran. 2021;48: 208. https://doi.org/10.55175/cdk.v48i4.1361
Smolle C, Cambiaso-Daniel J, Forbes AA, Wurzer P, Hundeshagen G, Branski LK, et al. Recent trends in burn epidemiology worldwide: A systematic review. Burns. 2017;43: 249-257. https://doi.org/10.1016/j.burns.2016.08.013
Opriessnig E, Luze H, Smolle C, Draschl A, Zrim R, Giretzlehner M, et al. Epidemiology of burn injury and the ideal dressing in global burn care - Regional differences explored. Burns. 2023;49: 1-14. https://doi.org/10.1016/j.burns.2022.06.018
Maciel AB da S, Ortiz JF, Siqueira BS, Zanette GF. Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials. An Bras Dermatol. 2019;94: 204-210. https://doi.org/10.1590/abd1806-4841.20198321
Lumintang L, Adnyana MS, Riasa INP, Asmarajaya AAGN, Hamid AR, Sanjaya H. A Systematic Review: Topical Sucralfate for Burn Wound. Open Access Maced J Med Sci. 2021;9: 516-522. https://doi.org/10.3889/oamjms.2021.6253
Levin NJ, Erben Y, Li Y, Brigham TJ, Bruce AJ. A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera. Cureus. 2022. https://doi.org/10.7759/cureus.30815
Khansa I, Schoenbrunner AR, Kraft CT, Janis JE. Silver in Wound Care-Friend or Foe?: A Comprehensive Review. Plast Reconstr Surg Glob Open. 2019;7: e2390. https://doi.org/10.1097/GOX.0000000000002390
Tenenhaus M, Rennekampff H-O. Topical agents and dressings for local burn wound care. In: Post TedW, editor. UpToDate. Waltham, MA: UpToDate; 2023. Available: www.uptodate.com
Cai EZ, Ang CH, Raju A, Tan KB, Hing ECH, Loo Y, et al. Creation of consistent burn wounds: A rat model. Arch Plast Surg. 2014;41: 317-324. https://doi.org/10.5999/aps.2014.41.4.317
Abdullahi A, Amini-Nik S, Jeschke MG. Animal models in burn research. Cellular and Molecular Life Sciences. Birkhauser Verlag AG; 2014. pp. 3241-3255. https://doi.org/10.1007/s00018-014-1612-5
Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, et al. Burn wound healing and treatment: Review and advancements. Critical Care. BioMed Central Ltd.; 2015. https://doi.org/10.1186/s13054-015-0961-2
Chen ZC, Wu SYS, Su WY, Lin YC, Lee YH, Wu WH, et al. Anti-inflammatory and burn injury wound healing properties of the shell of Haliotis diversicolor. BMC Complement Altern Med. 2016;16. https://doi.org/10.1186/s12906-016-1473-6
Widgerow AD, King K, Tocco-Tussardi I, Banyard DA, Chiang R, Awad A, et al. The burn wound exudate - An under-utilized resource. Burns. Elsevier Ltd; 2015. pp. 11-17. https://doi.org/10.1016/j.burns.2014.06.002
Sood A, Granick MS, Tomaselli NL. Wound Dressings and Comparative Effectiveness Data. Adv Wound Care (New Rochelle). 2014;3: 511-529. https://doi.org/10.1089/wound.2012.0401
Landén NX, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences. Birkhauser Verlag AG; 2016. pp. 3861-3885. https://doi.org/10.1007/s00018-016-2268-0
Wiegand C, Abel M, Hipler UC, Elsner P. Effect of non-adhering dressings on promotion of fibroblast proliferation and wound healing in vitro. Sci Rep. 2019;9. https://doi.org/10.1038/s41598-019-40921-y
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