THE EFFECT OF MAJA FRUIT [Aegle marmelos (L) Correa] ON INFLAMMATION MARKERS INVOLVED IN THE AGING PROCESS

David Limanan, NO Christian, E Efrany, E Yulianti, Frans Ferdinal

Abstract


Background: Aging is a process that every living creature will pass through and involves various factors. Increased inflammatory factors can be caused by hypoxia which forms Reactive Oxygen Species (ROS) and damages macromolecules and causes the acceleration of the aging process. Maja plants, empirically have long been used as medicinal plants, research on Maja leaves shows anti-inflammatory and antioxidant potential.

Objective: The purpose of this study was to find out and understand the potential of Maja fruit in the presence of inflammatory markers of IL-6 and TNF-α which are involved in the aging process.

Methods: This research was in vivo experimental, using male experimental animals Sprague Dawley rats divided into 8 groups (n = 4), and divided into 2 groups (fed with Maja ethanol extract (400 mg/ kg/day, 14 days) and not force-fed). Each group was divided into 4 subgroups (normoxia, hypoxia (O2 8%, N2 92%) for 3, 7 and 14 days). At the end of the trial period, animal blood was examined for IL-6 and TNF-α concentrations using the ELISA method.

Results: The results showed an increase in levels of IL-6 and TNF-α both in the group fed and not fed in line with the duration of hypoxia when compared with controls. However, groups that are not force-fed show a higher pattern compared to those who are force-fed.

Conclusion : The ethanol extract of Maja fruit can help slow down the aging process.


Full Text:

PDF

References


Kennely P. The Biochemistry of Aging. In: Rodwel V, Bender D, Botham K, Kennelly,Weil P. Harper’s Illustrated Biochemistry. 30th Ed. McGrraw-Hill. United States. 2015. 755-67.

Bruunsgaard H, Skinhoj P, Pedersen N, Sschroll M, Pedersen K. Ageing, tumour necrosis factor-alpha (TNF-a) and atherosclerosis. Clin Exp Immunol. 2000;121:255-60.

Frijhoff J, Winyard P, Zarkovic N, Davies S, Stocker R, Cheng D. Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants and Redox Signaling. 2015;23(14):1144-70.

Burton G, Jauniaux E. Oxidative stress. In : Arulkumaran S, Modder J (Ed). Best parctice and research clinical obstetrics and gynaecology. Elsevier. 2011;25:287 – 99.

Knuppel R, Hassan M, McDermott J, et al. Oxidative Stress and Antioxidants: Preterm Birth and Preterm Infants. In : Child John Morrison (Ed.). Preterm Birth - Mother and child. Intech. Croatia. 2012;125-50.

Gitto E, D’Angelo G, Cusumano E, Reiter R. Oxidative Stress of Newborn. In: Dr. Öner Özdemir (Ed.). Complementary Pediatrics. Intech. Croatia. 2012;73-96.

Dhankhar S, Ruhil S, Balhara M, Dhankar S, Chhillar A. Aegle Marmelos (Linn) Corre: A potential Source of Phytomedicine. J Med Plant Res. 2011;5(9):1497-507.

Rahman S, Parvin R. Therapeutic potential of Aegel Marmelos-An overview. Asian Pac J Trop Dis.2014;4(1):71-7.

Li SJ, Liu W, Wang JL, Zhang Y, Zhao DJ, Wang TJ, Li YY. The role of TNF-α, IL-6, IL-10, and GDNF in neuronal apoptosis in neonatal rat with hypoxic-ischemic encephalopathy. European Review for Medical and Pharmacological Sciences. 2014;18:905-9.

Bahera JP, Mohanty B, Ramani YR, Rath B, Pradhana S. Effect of aqueous extract of Aegle Marmelos unripe fruit on inflammatory bowel disease. Indian Journal of Pharmacology. 2012;44(5):614-8.

Kuznicka M, Owczarz M, Tobis K, Nadrowski P, Chudek J. Interleuikin-6 and C-reactive protein successful aging, and mortality: the possenior study. Immunity and ageing. 2016:13(21):1-12.

Sedger L, McDermott M. TNF and TNF-receptor: from mediators of cell death and inflammation to therapeutic giants. Cytokine and Growth Factor Review.2014:25(4):453-72.

Arul V, Miyazaki S, Dhananjayan R (2005). Studies on the antiinflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Correa. J. Ethnopharmacol., 96: 159.

Sedger L, McDermott M. TNF and TNF-receptor: from mediators of cell death and inflammation to therapeutic giants. Cytokine and Growth Factor Review.2014:25(4):453-72.




DOI: https://doi.org/10.32889/actabioina.v1i1.4

Article Metrics

Abstract view : 290 times
PDF - 125 times

Refbacks

  • There are currently no refbacks.




 

Lisensi Creative Commons

Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi-NonKomersial 4.0 Internasional.