Role of heme in cell proliferation and malignancy

  • Raisa Nauli Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
  • Sri Widia A Jusman Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia https://orcid.org/0000-0003-0471-5583
Keywords: heme biosynthesis, hemoprotein, inhibition of heme biosynthesis, cancer cell proliferation

Abstract

Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitochondria. Some cancer cells have more heme biosynthesis than normal cells, which is thought to be linked to more cancer cell growth. Inhibition of heme biosynthesis in some cancer cells leads to decreased cell proliferation. This review article discusses the synthesis of heme, the role of heme in energy metabolism, which is needed for cell proliferation, the inhibition of heme synthesis and its effect on cancer cell proliferation, and the possibility of the inhibition of heme biosynthesis as an approach in therapy of cancer in the future.

 

 

 

Author Biographies

Raisa Nauli, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia

 

 

Sri Widia A Jusman, Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia

 

 

 

Published
2022-12-31
How to Cite
Nauli, R., & Jusman, S. W. A. (2022). Role of heme in cell proliferation and malignancy. Acta Biochimica Indonesiana, 5(2), 65. https://doi.org/10.32889/actabioina.65