Ria Amelia, Neni Arshita, Siti Nur Fajriah, Chandra Vina Dwi Astuti, Islamiyah Nurul Fitri


Background: During the development of chronic type 2 diabetes mellitus (T2DM), inflammatory signals are elevated which can cause microvascular damage. C-Reactive Protein (CRP) is one of acute phase proteins stimulated under inflammatory conditions and creatinine is a waste product used to measure the glomerular filtration rate (GFR). Both of these compounds are considered as biomarkers of acute kidney damage among people with T2DM.  

Objective: The purpose of this study was to determine relationship between CRP and creatinine levels in T2DM patients.

Methods: We conducted analytic cross-sectional study in Kota Baru and Kalibaru sub-districts, Bekasi, from January until February 2019. Creatinine was measured using the jaffe method and CRP was measured using a latex agglutination technique. The correlation between CRP and creatinine was analyzed with Spearman test.

Results: Spearman correlation test from 55 samples showed a weak positive correlation (r = 0.289 ; p < 0.05) between CRP levels and creatinine levels. These results indicate that high CRP levels are directly proportional to creatinine levels in the serum of T2DM patients. Creatinine and CRP levels can be used as clinical parameters as biomarker for acute microvascular damage in nephron cells that can develop into complications due to T2DM.

Conclusion: There was a significant, weak positive correlation between CRP levels and creatinine levels in T2DM patients in Kota Baru and Kalibaru districts, Bekasi

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Zheng Y, Ley S, Hu F. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14:88–98.

International Diabetes Federation Chapter in a Book: The Global Burden. In: Diabetes Atlas Seven Edition.International Diabetes. Belgium: International Diabetes Federation. 2015. 16-17.

Akbari M, Vahideh HZ. Il‑6 signalling pathways and the development of type 2 diabetes. Inflammopharmacology. 2017; 26(3):685-698

Alnaas AA, Carrie LM, Mitchell A, Scott MR, Michelle KK. Conformational changes in C-reactive protein affect binding to curved membranes in a lipid bilayer model of the apoptotic cell surface. J. Phys. Chem. B 2017; 121: 2631−2639.

Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front. Immunol. 2018; 9:754.

Feng M, Min K, Feng H, Zonghui X, Zhewei L, Hailan Y, Jianxin W. Plasma interleukin‑37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients. Transl Med. 2018; 16:277.

Hellberg L, Sabrina F, Christoph G, Arup S, Martina B, Werner S, et al. Proinflammatory stimuli enhance phagocytosis of apoptotic cells by neutrophil granulocytes. The Scientific World Journal. 2011;11:2230–36.

Onuigbo JNN, Unuigbe EI, Kalu OA, Oguejiofor CO, Onuigbo PC. Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state South-East Nigeria. Niger. J Clin Pract. 2011; 14: 171-5.

Chawla A, Chawla R., Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?. Indian journal of endocrinology and metabolism. 2016;20 (4):546–551.

Radica ZA, Michele TR, Katherine RT. Diabetic kidney disease challenges, progress, and possibilities. Clin J Am Soc Nephrol. 2017; 12: 2032–2045.

Desi, Rini WN, Halim R. Determinan diabetes mellitus tipe 2 di Kelurahan Talang Bakung Kota Jambi. Jurnal Kesmas Jambi. 2018;2(1):50-58.

Isnaini N, Ratnasari. Faktor resiko mempengaruhi kejadian diabetes melitus tipe 2. Jurnal Keperawatan dan Kebidanan, 2018; 14(1): 59-68.

Matsui S, Yasui T, Tani A, Kunimi K, Uemura H, Yamamoto S. Association of estrogen and testosterone with insulin resistance in pre- and postmenopausal women with and without hormone therapy. Int J Endocrinol Metab. 2013; 11(2):65-70.

Peisajovich A, Marnell L, Mold C, Clos TWD. C-reactive protein at the interface between innate immunity and inflammation. Expert Reviews. Clin: Immunol. 2008;4(3): 379-390.

Kalma. Studi kadar C-reaktif protein (CRP) pada penderita diabetes mellitus tipe 2. Jurnal Media Analis Kesehatan. 2018; 1(1): 62-68.

Marcovecchio ML, Marta L, and Francesco C. Role of chronic and acute hyperglycemia in the development of diabetes complications. Diabetes Technology & Therapeutics. 2011;13(3):389-394.

Shaheer AK, Jithesh KT, Parvathi WK. A comparative study of high sensitivity c-reactive protein and metabolic variables in type 2 diabetes mellitus with and without nephropathy. Journal of Clinical and Diagnostic Research. 2017; 11(9):BC01-BC04.

You Y, Huang X, Chen H, Xia-Fei L, Hua-Feng L, Hui YL. C-reactive protein promotes diabetic kidney disease in db/db mice via the cd32b-smad3-mtor signaling pathway. Sci Rep. 2016; 6: 26740.

Takeuchi M, Hironori I, Isao M, Yuji S, Mina HT, Akihiko KA, et al. Serum creatinine levels and risk of incident type 2 diabetes mellitus or dysglycemia in middle-aged Japanese men: a retrospective cohort study. BMJ Open Diab Res Care. 2018;6: 1-7.

DOI: https://doi.org/10.32889/actabioina.v2i2.38

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